Buy Zofran Online

What is Zofran?

Zofran (ondansetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Zofran is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy or radiation).

Zofran may be used for purposes not listed in this medication guide.

Important information about Zofran

You should not use Zofran if you are allergic to ondansetron or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi). Do not take Zofran if you are also using apomorphine (Apokyn).

Before taking Zofran, tell your doctor if you have liver disease, or a personal or family history of Long QT syndrome.

Zofran orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

The serious side effects of this medication include blurred vision or temporary vision loss (lasting from only a few minutes to several hours), slow heart rate, trouble breathing, anxiety, agitation, shivering, feeling like you might pass out, and urinating less than usual or not at all. Stop taking Zofran and call your doctor at once if you have any of these side effects.

This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Before taking Zofran

You should not use Zofran if you are allergic to ondansetron, to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi). Do not take Zofran if you are also using apomorphine (Apokyn).

To make sure you can safely take Zofran, tell your doctor if you have any of these other conditions:

  • liver disease;

  • heart disease, congestive heart failure, a heart rhythm disorder;

  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or

  • a personal or family history of Long QT syndrome.

FDA pregnancy category B. Zofran is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Ondansetron should not be given to a child younger than 4 years old.

Zofran orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

How should I take Zofran?

Take Zofran exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Zofran can be taken with or without food.

Take the Zofran regular tablet with a full glass of water.

To take orally disintegrating tablet (Zofran ODT):

  • Keep the tablet in its blister pack until you are ready to take the medicine. Open the package and peel back the foil from the tablet blister. Do not push a tablet through the foil or you may damage the tablet.

  • Using dry hands, remove the tablet and place it in your mouth. It will begin to dissolve right away.

  • Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.

  • Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

Measure the liquid form of Zofran with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Your heart function may need to be tested with an electrocardiogram (ECG or EKG) on a regular basis. Do not miss any follow-up visits to your doctor.

Store Zofran at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting.

What should I avoid while taking Zofran?

Zofran may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Zofran side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Zofran: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • blurred vision or temporary vision loss (lasting from only a few minutes to several hours);

  • severe dizziness, feeling short of breath, fainting, fast or pounding heartbeats;

  • slow heart rate, trouble breathing;

  • anxiety, agitation, shivering;

  • feeling like you might pass out; or

  • urinating less than usual or not at all.

Less serious Zofran side effects may include:

  • diarrhea or constipation;

  • weakness or tired feeling;

  • fever;

  • headache; or

  • dizziness, drowsiness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Zofran?

Tell your doctor about all other medicines you use, especially:

  • arsenic trioxide (Trisenox);

  • tacrolimus (Prograf);

  • tramadol (Ultram, Ultracet);

  • an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), levofloxacin (Levaquin), moxifloxacin (Avelox), pentamidine (NebuPent, Pentam), or rifampin (Rifadin, Rimactane, Rifater);

  • an antidepressant such as amitriptylline (Elavil, Vanatrip, Limbitrol), clomipramine (Anafranil), or desipramine (Norpramin);

  • anti-malaria medications such as chloroquine (Aralen) or mefloquine (Lariam);

  • heart rhythm medicine such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), disopyramide (Norpace), dronedarone (Multaq), ibutilide (Corvert), procainamide (Procan, Pronestyl), propafenone (Rythmol), quinidine (Quin-G), or sotalol (Betapace);

  • medicine to prevent or treat nausea and vomiting such as dolasetron (Anzemet), droperidol (Inapsine), or ondansetron;

  • medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (FazaClo, Clozaril), haloperidol (Haldol), pimozide (Orap), thioridazine (Mellaril), or ziprasidone (Geodon);

  • migraine headache medicine such as sumatriptan (Imitrex, Treximet) or zolmitriptan (Zomig);

  • narcotic medication such as methadone (Methadose, Diskets, Dolophine); or

  • seizure medication such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin), or phenobarbital (Luminal).

This list is not complete and other drugs may interact with Zofran. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

For the Consumer

Applies to ondansetron: film, solution, tablet, tablet disintegrating

Along with its needed effects, ondansetron (the active ingredient contained in Zofran) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ondansetron:

More common
  • Confusion
  • dizziness
  • fast heartbeat
  • fever
  • headache
  • shortness of breath
  • weakness
Less common
  • Decrease in the frequency of urination
  • decrease in urine volume
  • difficulty with passing urine (dribbling)
  • painful urination
Rare
  • Arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • convulsions
  • cough
  • decreased urine
  • difficulty with breathing
  • difficulty with swallowing
  • dry mouth
  • fast, pounding, or irregular heartbeat or pulse
  • hives
  • increased thirst
  • itching
  • loss of appetite
  • loss of bladder control
  • loss of consciousness
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • noisy breathing
  • numbness or tingling in the hands, feet, or lips
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash
  • sweating
  • tightness in the chest
  • total body jerking
  • unusual tiredness or weakness
  • wheezing
Incidence not known
  • Blurred vision
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fixed position of the eye
  • heart stops
  • hoarseness
  • inability to move the eyes
  • increased blinking or spasms of the eyelid
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • no breathing
  • no pulse or blood pressure
  • noisy breathing
  • pounding heartbeat
  • slow or irregular breathing
  • sticking out of the tongue
  • sweating
  • trouble with breathing, speaking, or swallowing
  • unconscious
  • uncontrolled twisting movements of the neck, trunk, arms, or legs
  • unusual facial expressions

Some side effects of ondansetron may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Anxiety
  • difficulty having a bowel movement (stool)
  • dry mouth
  • general feeling of discomfort or illness
  • hyperventilation
  • irritability
  • restlessness
  • shaking
  • trouble sleeping
Rare
  • Difficulty with speaking
  • drooling
  • loss of balance control
  • muscle trembling, jerking, or stiffness
  • shuffling walk
  • stiffness of the limbs
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back
Incidence not known
  • Feeling of warmth
  • hiccups
  • hives or welts
  • redness of the face, neck, arms, and occasionally, upper chest
  • redness of the skin

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Applies to ondansetron: injectable solution, intravenous solution, oral disintegrating strip, oral solution, oral tablet, oral tablet disintegrating

General

In general, headache is the most common adverse effect reported. Transient dizziness during or shortly after the IV infusion has also been reported during postmarketing experience.

Gastrointestinal

A causal relationship between intestinal obstruction and ondansetron (the active ingredient contained in Zofran) has not been established.

Gastrointestinal side effects including constipation (up to 15%) and diarrhea have been reported. Several cases of intestinal obstruction have been reported. Nausea and vomiting have been reported with the use of intravenous ondansetron during postmarketing experience.

Hepatic

Hepatic side effects have included mild elevations of liver function tests. The clinical significance of these elevations is unknown. Cases of jaundice have also been reported rarely. One case of pancreatitis was reported in a patient using ondansetron (the active ingredient contained in Zofran) long-term. Liver failure and death have been reported in patients with cancer receiving concurrent medications, including potentially hepatotoxic cytotoxic chemotherapy and antibiotics, and intravenous ondansetron during postmarketing experience.

Cardiovascular

One study has suggested that prolongation of the QTc interval may occur in many patients treated with cisplatin and ondansetron (the active ingredient contained in Zofran) simultaneously. In that study QTc prolongation occurred in 6 of 8 patients who received a combination of ondansetron and cisplatin. Five of the patients had prolongations of the QTc interval which were greater than 5%. However, no episodes of arrhythmia, hypotension, ischemia, congestive heart failure or other cardiovascular events were observed.

Similarly, results of a review of the cardiovascular effects of the drug class 5-hydroxytryptamine 3 receptor antagonists in the literature reported that electrocardiographic (ECG) changes were so small to be considered clinically insignificant. ECG changes were most noticeable between 1 to 2 hours after a dose of ondansetron and returned to baseline within 24 hours. To date, no serious cardiac side effects (including torsades de pointes) triggered by ECG interval changes have been connected with the use of 5-HT 3 receptor antagonists.

Cardiovascular side effects have rarely included angina and acute myocardial ischemia. Arrhythmias (including ventricular and supraventricular tachycardia, premature ventricular contractions, and atrial fibrillation), bradycardia, electrocardiographic alterations (including second-degree heart block, QT interval prolongation, and ST segment depression), palpitations, syncope, Torsade de points, ventricular fibrillation, and chest discomfort have been reported with the use of intravenous ondansetron during postmarketing experience.

Hypersensitivity

Hypersensitivity side effects have rarely included rashes. Twenty-four reports of anaphylactoid-anaphylactic reactions following intravenous administration of ondansetron (the active ingredient contained in Zofran) have been reported in postmarketing experience. One report suggests hypersensitivity reactions with 5-HT 3-antagonists may be a class effect and cross-reactive.

Psychiatric

Psychiatric side effects have rarely included depression.

A brief episode of ondansetron-induced depression has been reported in one woman whose depression was controlled with fluoxetine. A 41-year-old woman became suicidally depressed seven days after receiving ondansetron prior to arthroscopy. The depression was controlled with fluvoxamine, alprazolam, and flunitrazepam.

Dermatologic

Dermatologic side effects have included pruritus (5%) and rash (1%). A suspected fixed drug eruption with the lesions appearing macular and pruritic has also been reported. Rechallenge lead to regression of the lesions. Urticaria, hyperhidrosis, pruritus, and purpura have been reported with the use of intravenous ondansetron (the active ingredient contained in Zofran) during postmarketing experience.

Nervous system

Nervous system side effects have included dizziness (18%) and extrapyramidal reactions, including twitching tremors, opisthotonos, severe jerking movements, and numbness. In many of these cases, diphenhydramine (25 mg to 50 mg) was effective for treatment or prevention. Chills, lethargy, and oculogyric crisis, appearing alone, as well as with other dystonic reactions have also been reported with the use of intravenous ondansetron (the active ingredient contained in Zofran) during postmarketing experience.

Rechallenge with ondansetron lead to a reoccurrence of the opisthotonos in one patient. Patients with a history of drug-induced dystonic reactions may have a similar response after ondansetron therapy.

Ocular

Ocular side effects have rarely included blurred vision, in some cases associated with abnormalities of accommodation. Rare cases of transient blindness have also been reported, predominantly during intravenous administration.

Transient blindness (a duration of 2 to 3 minutes) generally resolved within 20 minutes up to 48 hours.

Respiratory

Respiratory side effects have included hiccups with the use of intravenous ondansetron (the active ingredient contained in Zofran) during postmarketing experience.

Local

Local side effects have included pain, redness, and burning at injection site with the use of intravenous ondansetron (the active ingredient contained in Zofran) during postmarketing experience.

Musculoskeletal

Musculoskeletal side effects have included arthralgia reported with the use of intravenous ondansetron (the active ingredient contained in Zofran) during postmarketing experience.